Abstract
Sebaceous skin tumors are classified into sebaceous adenoma, sebaceoma, and sebaceous
carcinoma. An additional group of cystic sebaceous tumors indicate the Muir-Torre
syndrome (MTS). Cystic sebaceous tumors are considered as morphologic variants of
the 3 main categories. Multilineage adnexal tumors with partly sebaceous differentiation
may pose a challenge to categorize. Sebaceous hyperplasia and nevus sebaceus are not
considered as true sebaceous tumor entities. Recently, attention has been drawn to
morphologic clues of sebaceous differentiation. Immunohistochemistry using the mismatch
repair proteins and/or genetic microsatellite instability testing should be performed
on sebaceous neoplasms to diagnose MTS as early as possible.
Keywords
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