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Review Article| Volume 16, ISSUE 1, P27-44, March 2023

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Challenges in Encapsulated Follicular-Patterned Tumors: How Much Is Enough? Evaluation of Nuclear Atypia, Architecture, and Invasion

  • Author Footnotes
    1 Present address: 75 Francis Street, Boston, MA 02115.
    Kristine S. Wong
    Footnotes
    1 Present address: 75 Francis Street, Boston, MA 02115.
    Affiliations
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Search for articles by this author
  • Author Footnotes
    1 Present address: 75 Francis Street, Boston, MA 02115.
    Justine A. Barletta
    Correspondence
    Corresponding author.
    Footnotes
    1 Present address: 75 Francis Street, Boston, MA 02115.
    Affiliations
    Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Search for articles by this author
  • Author Footnotes
    1 Present address: 75 Francis Street, Boston, MA 02115.
Published:December 12, 2022DOI:https://doi.org/10.1016/j.path.2022.09.005

      Keywords

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      References

        • Tallini G.
        • Tuttle R.M.
        • Ghossein R.A.
        The history of the follicular variant of papillary thyroid carcinoma.
        J Clin Endocrinol Metab. 2017; 102: 15-22
        • Chen K.T.K.
        • Rosai J.
        Follicular variant of thyroid papillary carcinoma: A clinicopathologic study of six cases.
        Am J Surg Pathol. 1977; 1: 123-130
        • Jung C.K.
        • Little M.P.
        • Lubin J.H.
        • et al.
        The increase in thyroid cancer incidence during the last four decades is accompanied by a high frequency of BRAF mutations and a sharp increase in RAS mutations.
        J Clin Endocrinol Metab. 2014; 99: 276-285
        • Sangalli G.
        • Serio G.
        • Zampatti C.
        • et al.
        Fine needle aspiration cytology of the thyroid: a comparison of 5469 cytological and final histological diagnoses.
        Cytopathology. 2006; 17: 245-250
        • Medici M.
        • Liu X.
        • Kwong N.
        • et al.
        Long- versus short-interval follow-up of cytologically benign thyroid nodules: A prospective cohort study.
        BMC Med. 2016; 14: 1-9
        • Lloyd R v
        • Erickson L.A.
        • Casey M.B.
        • et al.
        Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma.
        Am J Surg Pathol. 2004; 28: 1336-1340
        • Elsheikh T.M.
        • Asa S.L.
        • Chan J.K.C.
        • et al.
        Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma.
        Am J Clin Pathol. 2008; 130: 736-744
        • Hirokawa M.
        • Carney J.A.
        • Goellner J.R.
        • et al.
        Observer Variation of Encapsulated Follicular Lesions of the Thyroid Gland.
        Am J Surg Pathol. 2002; 26: 1508-1514
        • Liu J.
        • Singh B.
        • Tallini G.
        • et al.
        Follicular variant of papillary thyroid carcinoma: A clinicopathologic study of a problematic entity.
        Cancer. 2006; 107: 1255-1264
        • Rivera M.
        • Ricarte-Filho J.
        • Knauf J.
        • et al.
        Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
        Mod Pathol. 2010; 23: 1191-1200
        • Howitt B.E.
        • Jia Y.
        • Sholl L.M.
        • et al.
        Molecular Alterations in Partially-Encapsulated or Well-Circumscribed Follicular Variant of Papillary Thyroid Carcinoma.
        Thyroid. 2013; 23: 1256-1262
        • Nikiforov Y.E.
        • Seethala R.R.
        • Tallini G.
        • et al.
        Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma a paradigm shift to reduce overtreatment of indolent tumors.
        JAMA Oncol. 2016; 2: 1023-1029
        • Seethala R.R.
        • Baloch Z.W.
        • Barletta J.A.
        • et al.
        Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A review for pathologists.
        Mod Pathol. 2018; 31: 39-55
        • Vanzati A.
        • Mercalli F.
        • Rosai J.
        The “sprinkling” sign in the follicular variant of papillary thyroid carcinoma: A clue to the recognition of this entity.
        Arch Pathol Lab Med. 2013; 137: 1707-1709
        • Thompson L.D.R.
        • Poller D.N.
        • Kakudo K.
        • et al.
        An International Interobserver Variability Reporting of the Nuclear Scoring Criteria to Diagnose Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: a Validation Study.
        Endocr Pathol. 2018; 29: 242-249
        • Lee S.E.
        • Hwang T.S.
        • Choi Y la
        • et al.
        Molecular profiling of papillary thyroid carcinoma in korea with a high prevalence of BRAFV600E mutation.
        Thyroid. 2017; 27: 802-810
        • Bychkov A.
        • Jung C.K.
        • Liu Z.
        • et al.
        Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology.
        Endocr Pathol. 2018; 29: 276-288
        • Rana C.
        • Vuong H.G.
        • Nguyen T.Q.
        • et al.
        The Incidence of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Meta-Analysis Assessing Worldwide Impact of the Reclassification.
        Thyroid. 2021; 31: 1502-1513
        • Thompson L.D.
        Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: A name change to Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features would help prevent overtreatment.
        Mod Pathol. 2016; 29: 698-707
        • Paja M.
        • Zafón C.
        • Iglesias C.
        • et al.
        Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist’s criteria: a multicentre retrospective Southern European study with prolonged follow-up.
        Endocrine. 2021; 73: 131-140
        • Marcadis A.R.
        • Valderrabano P.
        • Ho A.S.
        • et al.
        Interinstitutional variation in predictive value of the ThyroSeq v2 genomic classifier for cytologically indeterminate thyroid nodules.
        Surgery (United States). 2018; 0: 1-8
        • Kitahara C.M.
        • Sosa J.A.
        • Shiels M.S.
        Influence of nomenclature changes on trends in papillary thyroid cancer incidence in the united states, 2000 to 2017.
        J Clin Endocrinol Metab. 2020; 105https://doi.org/10.1210/clinem/dgaa690
        • Caulley L.
        • Eskander A.
        • Yang W.
        • et al.
        Trends in Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillarylike Nuclear Features and Total Thyroidectomies for Patients with Papillary Thyroid Neoplasms.
        JAMA Otolaryngol - Head Neck Surg. 2022; 148: 99-106
        • Ferris R.L.
        • Nikiforov Y.
        • Terris D.
        • et al.
        AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
        Head Neck. 2018; 40: 1881-1888
        • Rosario P.W.
        • Mourão G.F.
        Follow-up of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
        Head Neck. 2019; 41: 833-834
        • WHO Classification of Tumours Editorial Board
        Endocrine and neuroendocrine Tumours.
        5th edition. International Agency for Research on Cancer, 2022
        • Pereira M.
        • Williams V.L.
        • Hallanger Johnson J.
        • et al.
        Thyroid cancer incidence trends in the United States: Association with changes in professional guideline recommendations.
        Thyroid. 2020; 30: 1132-1140
        • Sugino K.
        • Kameyama K.
        • Ito K.
        • et al.
        Does Hürthle cell carcinoma of the thyroid have a poorer prognosis than ordinary follicular thyroid carcinoma?.
        Ann Surg Oncol. 2013; 20: 2944-2950
        • Jeong S.H.
        • Hong H.S.
        • Kwak J.J.
        • et al.
        Analysis of RAS mutation and PAX8/PPARγ rearrangements in follicular-derived thyroid neoplasms in a Korean population: Frequency and ultrasound findings.
        J Endocrinol Invest. 2015; 38: 849-857
        • Vivero M.
        • Kraft S.
        • Barletta J.A.
        Risk stratification of follicular variant of papillary thyroid carcinoma.
        Thyroid. 2013; 23: 273-279
        • Rivera M.
        • Tuttle R.M.
        • Patel S.
        • et al.
        Encapsulated papillary thyroid carcinoma: a clinico-pathologic study of 106 cases with emphasis on its morphologic subtypes (histologic growth pattern).
        Thyroid. 2009; 19: 119-127
        • Kim T.H.
        • Lee M.
        • Kwon A.Y.
        • et al.
        Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma.
        Histopathology. 2018; 72: 648-661
        • Odate T.
        • Oishi N.
        • Vuong H.G.
        • et al.
        Genetic differences in follicular thyroid carcinoma between Asian and Western countries: a systematic review.
        Gland Surg. 2020; 9: 1813-1826
        • Nikiforov Y.E.
        • Baloch Z.W.
        • Hodak S.P.
        • et al.
        Change in diagnostic criteria for noninvasive follicular thyroid neoplasm with papillarylike nuclear features.
        JAMA Oncol. 2018; 4: 1125-1126
        • Cho U.
        • Mete O.
        • Kim M.H.
        • et al.
        Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: The impact of rigid criteria to distinguish non-invasive follicular thyroid neoplasm with papillary-like nuclear features.
        Mod Pathol. 2017; 30: 810-825
        • Kim M.J.
        • Won J.K.
        • Jung K.C.
        • et al.
        Clinical Characteristics of Subtypes of Follicular Variant Papillary Thyroid Carcinoma.
        Thyroid. 2018; 28: 311-318
        • Parente D.N.
        • Kluijfhout W.P.
        • Bongers P.J.
        • et al.
        Clinical Safety of Renaming Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: Is NIFTP Truly Benign?.
        World J Surg. 2018; 42: 321-326
        • Xu B.
        • Serrette R.
        • Tuttle R.M.
        • et al.
        How many papillae in conventional papillary carcinoma? A clinical evidence-based pathology study of 235 unifocal encapsulated papillary thyroid carcinomas, with emphasis on the diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features.
        Thyroid. 2019; 29: 1792-1803
        • Xu B.
        • Reznik E.
        • Tuttle R.M.
        • et al.
        Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features.
        Endocrine. 2019; 64: 97-108
        • Xu B.
        • Farhat N.
        • Barletta J.A.
        • et al.
        Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?.
        Endocrine. 2018; 59: 143-150
        • Xu B.
        • Tallini G.
        • Scognamiglio T.
        • et al.
        Outcome of Large Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.
        Thyroid. 2017; 27: 512-517
        • Agrawal N.
        • Akbani R.
        • Aksoy B.A.
        • et al.
        Integrated Genomic Characterization of Papillary Thyroid Carcinoma.
        Cell. 2014; 159: 676-690
        • Zhao L.
        • Dias-Santagata D.
        • Sadow P.M.
        • et al.
        Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma.
        Cancer Cytopathology. 2017; 125: 323-331
        • Paulson V.A.
        • Shivdasani P.
        • Angell T.E.
        • et al.
        Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features Accounts for More Than Half of “Carcinomas” Harboring RAS Mutations.
        Thyroid. 2017; 27: 506-511
        • Johnson D.N.
        • Sadow P.M.
        Exploration of BRAFV600E as a diagnostic adjuvant in the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).
        Hum Pathol. 2018; 82: 32-38
        • Mai K.T.
        • Landry D.C.
        • Thomas J.
        • et al.
        Follicular Adenoma with Papillary Architecture: A Lesion Mimicking Papillary Thyroid Carcinoma.
        Histopathology. 2001; 39: 25-32
        • Jing X.
        • Michael C.W.
        Potential pitfalls for false suspicion of papillary thyroid carcinoma: A Cytohistologic Review of 22 Cases.
        Diagn Cytopathol. 2012; 40https://doi.org/10.1002/dc.21726
        • Gorla S.
        • di Bella C.
        • Leone B.
        • et al.
        Cytological and histological findings of thyroid florid papillary hyperplasia.
        Cytopathology. 2012; 23: 417-419
        • Pusztaszeri M.P.
        • Krane J.F.
        • Cibas E.S.
        • et al.
        FNAB of benign thyroid nodules with papillary hyperplasia: A cytological and histological evaluation.
        Cancer Cytopathology. 2014; 122: 666-677
        • LiVolsi V.A.
        • Baloch Z.W.
        The Pathology of Hyperthyroidism.
        Front Endocrinol. 2018; 9https://doi.org/10.3389/fendo.2018.00737
        • Esapa C.
        • Foster S.
        • Johnson S.
        • et al.
        Protein and Thyrotropin Receptor Mutations inThyroid Neoplasia.
        J Clin Endocrinol Metab. 1997; 82: 493-496
        • Trülzsch B.
        • Krohn K.
        • Wonerow P.
        • et al.
        Detection of thyroid-stimulating hormone receptor and Gsα mutations: In 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.
        J Mol Med. 2001; 78: 684-691
        • Mon S.Y.
        • Riedlinger G.
        • Abbott C.E.
        • et al.
        Cancer risk and clinicopathological characteristics of thyroid nodules harboring thyroid-stimulating hormone receptor gene mutations.
        Diagn Cytopathol. 2018; 46: 369-377
        • Calebiro D.
        • Grassi E.S.
        • Eszlinger M.
        • et al.
        Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas.
        J Clin Invest. 2016; 126: 3383-3388
        • Guan H.
        • Matonis D.
        • Toraldo G.
        • et al.
        Clinical significance of thyroid-stimulating hormone receptor gene mutations and/or sodium-iodine symporter gene overexpression in indeterminate thyroid fine needle biopsies.
        Front Endocrinol. 2018; 9https://doi.org/10.3389/fendo.2018.00566
        • Stephenson A.
        • Eszlinger M.
        • Stewardson P.
        • et al.
        Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules.
        Thyroid. 2020; 30: 1482-1489
        • Landau M.S.
        • Nikiforov Y.E.
        • Ohori N.P.
        • et al.
        Impact of molecular testing on detecting mimics of oncocytic neoplasms in thyroid fine-needle aspirates diagnosed as follicular neoplasm of Hürthle cell (oncocytic) type.
        Cancer Cytopathology. 2021; 129: 788-797
        • Lado-Abeal J.
        • Celestino R.
        • Bravo S.B.
        • et al.
        Identification of a paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARγ) rearrangement mosaicism in a patient with an autonomous functioning follicular thyroid carcinoma bearing an activating mutation in the TSH receptor.
        Endocrine-Related Cancer. 2010; 17: 599-610
        • Stewart D.R.
        • Best A.F.
        • Williams G.M.
        • et al.
        Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1.
        J Clin Oncol. 2019; 37: 668-676
        • González I.A.
        • Stewart D.R.
        • Schultz K.A.P.
        • et al.
        DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
        Mod Pathol. 2022; 35: 4-22
        • Khan N.E.
        • Bauer A.J.
        • Schultz K.A.P.
        • et al.
        Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: A family-based cohort study.
        J Clin Endocrinol Metab. 2017; 102: 1614-1622
        • de Kock L.
        • Bah I.
        • Revil T.
        • et al.
        Deep sequencing reveals spatially distributed distinct hot spot mutations in DICER1-related multinodular goiter.
        J Clin Endocrinol Metab. 2016; 101: 3637-3645
        • Gullo I.
        • Batista R.
        • Rodrigues-Pereira P.
        • et al.
        Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome.
        Am J Clin Pathol. 2018; 149: 379-386
        • Juhlin C.C.
        • Stenman A.
        • Zedenius J.
        Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
        Histopathology. 2021; 79: 661-666
        • Mirshahi U.L.
        • Kim J.
        • Best A.F.
        • et al.
        A Genome-First Approach to Characterize DICER1 Pathogenic Variant Prevalence, Penetrance, and Phenotype.
        JAMA Netw Open. 2021; 4https://doi.org/10.1001/jamanetworkopen.2021.0112
        • Kim J.
        • Schultz K.A.P.
        • Hill D.A.
        • et al.
        The prevalence of germline DICER1 pathogenic variation in cancer populations.
        Mol Genet Genomic Med. 2019; 7https://doi.org/10.1002/mgg3.555
        • Evans D.G.
        • Howard E.
        • Giblin C.
        • et al.
        Birth incidence and prevalence of tumor-prone syndromes: Estimates from a UK family genetic register service.
        Am J Med Genet A. 2010; 152: 327-332
        • Chong A.S.
        • Nikiforov Y.E.
        • Condello V.
        • et al.
        Prevalence and spectrum of DICER1 mutations in adult-onset thyroid nodules with indeterminate cytology.
        J Clin Endocrinol Metab. 2021; 106: 968-977
        • Evans H.L.
        Follicular Neoplasms of the Thyroid A Study of 44 Cases Followed for a Minimum of 10 Years, With Emphasis on Differential Diagnosis.
        Cancer. 1984; 54: 535-540
        • Yamashina M.
        Follicular neoplasms of the thyroid. Total circumferential evaluation of the fibrous capsule.
        Am J Surg Pathol. 1992; 16: 392-400
        • Baloch Z.W.
        • LiVolsi V.A.
        Our approach to follicular-patterned lesions of the thyroid.
        J Clin Pathol. 2007; 60: 244-250
        • Sobrinho-Simões M.
        • Eloy C.
        • Magalhães J.
        • et al.
        Follicular thyroid carcinoma.
        Mod Pathol. 2011; 24: S10-S18
        • Mete O.
        • Seethala R.
        • Asa S.
        • et al.
        Protocol for the examination of specimens from patients with carcinomas of the thyroid gland, version 4.2.0.0.
        College of American Pathologists Cancer Protocol s, 2019 (Published online)
        • Thompson L.D.R.
        • Wieneke J.A.
        • Paal E.
        • et al.
        A Clinicopathologic Study of Minimally Invasive Follicular Carcinoma of the Thyroid Gland with a Review of the English Literature BACKGROUND. The criteria for minimally invasive (low grade) follicular carcinoma.
        Cancer. 2001; 91: 505-524
        • Xu B.
        • Teplov A.
        • Ibrahim K.
        • et al.
        Detection and assessment of capsular invasion, vascular invasion and lymph node metastasis volume in thyroid carcinoma using microCT scanning of paraffin tissue blocks (3D whole block imaging): a proof of concept.
        Mod Pathol. 2020; 33: 2449-2457
        • Franc B.
        • de La Salmonière P.
        • Lange F.
        • et al.
        Interobserver and Intraobserver Reproducibility in the Histopathology of Follicular Thyroid Carcinoma.
        Hum Pathol. 2003; 34: 1092-1100
        • Zhu Y.
        • Li Y.
        • Jung C.K.
        • et al.
        Histopathologic Assessment of Capsular Invasion in Follicular Thyroid Neoplasms—an Observer Variation Study.
        Endocr Pathol. 2020; 31: 132-140
        • Ghossein R.
        • Barletta J.A.
        • Bullock M.
        • et al.
        Data set for reporting carcinoma of the thyroid: recommendations from the International Collaboration on Cancer Reporting.
        Hum Pathol. 2021; 110: 62-72
        • Mete O.
        • Asa S.L.
        Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation.
        Mod Pathol. 2011; 24: 1545-1552
        • Cracolici V.
        • Parilla M.
        • Henriksen K.J.
        • et al.
        An Evaluation of CD61 Immunohistochemistry in Identification of Vascular Invasion in Follicular Thyroid Neoplasms.
        Head Neck Pathol. 2020; 14: 399-405
        • Nishino M.
        • Jacob J.
        Invasion in thyroid cancer: Controversies and best practices.
        Semin Diagn Pathol. 2020; 37: 219-227
        • Ghossein R.A.
        • Hiltzik D.H.
        • Carlson D.L.
        • et al.
        Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: A clinicopathologic study of 50 cases.
        Cancer. 2006; 106: 1669-1676
        • Ito Y.
        • Hirokawa M.
        • Masuoka H.
        • et al.
        Prognostic factors of minimally invasive follicular thyroid carcinoma: Extensive vascular invasion significantly affects patient prognosis.
        Endocr J. 2013; 60: 637-642
        • Xu B.
        • Wang L.
        • Tuttle R.M.
        • et al.
        Prognostic impact of extent of vascular invasion in low-grade encapsulated follicular cell-derived thyroid carcinomas: A clinicopathologic study of 276 cases.
        Hum Pathol. 2015; 46: 1789-1798
        • Matsuura D.
        • Yuan A.
        • Wang L.Y.
        • et al.
        Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
        Thyroid. 2022; 32: 245-254
        • Yamazaki H.
        • Katoh R.
        • Sugino K.
        • et al.
        Encapsulated Angioinvasive Follicular Thyroid Carcinoma: Prognostic Impact of the Extent of Vascular Invasion.
        Ann Surg Oncol. 2022; (Published online February 15)https://doi.org/10.1245/s10434-022-11401-x
        • Haugen B.R.
        • Alexander E.K.
        • Bible K.C.
        • et al.
        2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer.
        Thyroid. 2016; 26https://doi.org/10.1089/thy.2015.0020
        • Williams E.D.
        • Abrosimov A.
        • Bogdanova T.
        • et al.
        Guest editorial: two proposals regarding the terminology of thyroid tumors.
        Int J Surg Pathol. 2000; 8: 181-183
        • Hofman V.
        • Lassalle S.
        • Bonnetaud C.
        • et al.
        Thyroid tumours of uncertain malignant potential: Frequency and diagnostic reproducibility.
        Virchows Archiv. 2009; 455: 21-33
        • Piana S.
        • Frasoldati A.
        • Felice E di
        • et al.
        Encapsulated Well-Differentiated Follicular-Patterned Thyroid Carcinomas Do Not Play a Significant Role in the Fatality Rates From Thyroid Carcinoma.
        Am J Surg Pathol. 2010; 34: 868-872
        • Liu Z.
        • Zhou G.
        • Nakamura M.
        • et al.
        Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well-differentiated tumor of uncertain malignant potential: A morphological, immunohistochemical, and molecular appraisal.
        Cancer Sci. 2011; 102: 288-294
        • Baser H.
        • Topaloglu O.
        • Tam A.A.
        • et al.
        Comparing Clinicopathologic and Radiographic Findings Between TT-UMP, Classical, and Non-Encapsulated Follicular Variants of Papillary Thyroid Carcinomas.
        Endocr Pathol. 2016; 27: 233-242
        • Ito Y.
        • Hirokawa M.
        • Hayashi T.
        • et al.
        Clinical outcomes of follicular tumor of uncertain malignant potential of the thyroid: real-world data.
        Endocr J. 2022; (Published online)https://doi.org/10.1507/endocrj.ej21-0723
        • O’Neill C.J.
        • Vaughan L.
        • Learoyd D.L.
        • et al.
        Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion.
        Eur J Surg Oncol. 2011; 37: 181-185
        • Baloch Z.W.
        • Livolsi V.A.
        Encapsulated Follicular Variant of Papillary Thyroid Carcinoma with Bone Metastases.
        Mod Pathol. 2000; 13: 861-865
        • Lee Y.J.
        • Kim D.W.
        • Shin G.W.
        • et al.
        Unexpected Lung and Brain Metastases 9 Years After Thyroid Lobectomy for Follicular Adenoma: A Case Report.
        Front Endocrinol. 2019; 10https://doi.org/10.3389/fendo.2019.00783
        • Oh H.S.
        • Kim S.J.
        • Song E.
        • et al.
        Modified Transverse-Vertical Gross Examination: a Better Method for the Detection of Definite Capsular Invasion in Encapsulated Follicular-Patterned Thyroid Neoplasms.
        Endocr Pathol. 2019; 30: 106-112