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Review Article|Articles in Press

Breast Implant-Associated Anaplastic Large Cell Lymphoma

Updates in Diagnosis and Specimen Handling
Published:March 10, 2023DOI:https://doi.org/10.1016/j.path.2023.01.003

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      References

        • Keech Jr., J.A.
        • Creech B.J.
        Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant.
        Plast Reconstr Surg. 1997; 100: 554-555
        • Said J.W.
        • Tasaka T.
        • Takeuchi S.
        • et al.
        Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.
        Blood. 1996; 88: 3124-3128
        • Lyapichev K.A.
        • Medeiros L.
        • Clemens M.
        • et al.
        Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature.
        Ann Diagn Pathol. 2020; 45: 151474
        • Miranda R.N.
        • Feldman A.L.
        • Soares F.A.
        Breast implant-associated anaplastic large cell lymphoma.
        in: Allison K.H. Edi B. Ellis I.O. World Health Organization Breast Tumours. 5th edition. IARC, Lyon2019: 245-248
        • Alaggio R.
        • Amador C.
        • Anagnostopoulos I.
        • et al.
        The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.
        Leukemia. 2022; 36: 1720-1748
        • Oishi N.
        • Hundal T.
        • Phillips J.L.
        • et al.
        Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma.
        Haematologica. 2021; 106: 1714-1724
        • Talwalkar S.S.
        • Miranda R.N.
        • Valbuena J.R.
        • et al.
        Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms.
        Am J Surg Pathol. 2008; 32: 1299-1309
        • Kinslow C.J.
        • Kim A.
        • Sanchez G.I.
        • et al.
        Incidence of anaplastic large cell lymphoma of the breast in the US, 2000 to 2018.
        JAMA Oncol. 2022; 8: 1354-1356
        • Quesada A.E.
        • Medeiros L.J.
        • Clemens M.W.
        • et al.
        Breast implant-associated anaplastic large cell lymphoma: a review.
        Mod Pathol. 2019; 32: 166-188
        • Miranda R.N.
        • Aladily T.N.
        • Prince H.M.
        • et al.
        Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients.
        J Clin Oncol. 2014; 32: 114-120
        • Loch-Wilkinson A.
        • Beath K.J.
        • Magnusson M.R.
        • et al.
        Breast implant-associated anaplastic large cell lymphoma in Australia: a longitudinal study of implant and other related risk factors.
        Aesthet Surg J. 2020; 40: 838-846
        • de Boer M.
        • Hauptmann M.
        • Hijmering N.J.
        • et al.
        Increased prevalence of BRCA1/2 mutations in women with macrotextured breast implants and anaplastic large cell lymphoma of the breast.
        Blood. 2020; 136: 1368-1372
        • Collett D.J.
        • Rakhorst H.
        • Lennox P.
        • et al.
        Current risk estimate of breast implant-associated anaplastic large cell lymphoma in textured breast implants.
        Plast Reconstr Surg. 2019; 143: 30s-40s
        • Ionescu P.
        • Vibert F.
        • Amé S.
        • et al.
        New data on the epidemiology of breast implant-associated anaplastic large cell lymphoma.
        Eur J Breast Health. 2021; 17: 302-307
        • Santanelli di Pompeo F.
        • Clemens M.W.
        • Atlan M.
        • et al.
        2022 Practice recommendation updates from the World Consensus Conference on BIA-ALCL.
        Aesthet Surg J. 2022; 42: 1262-1278
        • Cordeiro P.G.
        • Ghione P.
        • Ni A.
        • et al.
        Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants.
        J Plast Reconstr Aesthet Surg. 2020; 73: 841-846
        • Magnusson M.
        • Beath K.
        • Cooter R.
        • et al.
        The Epidemiology of breast implant–associated anaplastic large cell lymphoma in Australia and New Zealand confirms the highest risk for grade 4 surface breast implants.
        Plast Reconstr Surg. 2019; 143: 1285-1292
        • Doren E.L.
        • Miranda R.N.
        • Selber J.C.
        • et al.
        • U.S
        Epidemiology of breast implant-associated anaplastic large cell lymphoma.
        Plast Reconstr Surg. 2017; 139: 1042-1050
        • Lynch E.B.
        • DeCoster R.C.
        • Vyas K.S.
        • et al.
        Current risk of breast implant-associated anaplastic large cell lymphoma: a systematic review of epidemiological studies.
        Ann Breast. 2021; 5: 30
        • Wang Y.
        • Zhang Q.
        • Tan Y.
        • et al.
        Current progress in breast implant-associated anaplastic large cell lymphoma.
        Front Oncol. 2021; 11: 785887
        • Roden A.C.
        • Macon W.R.
        • Keeney G.L.
        • et al.
        Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder.
        Mod Pathol. 2008; 21: 455-463
        • Story S.K.
        • Schowalter M.K.
        • Geskin L.J.
        Breast implant-associated ALCL: a unique entity in the spectrum of CD30+ lymphoproliferative disorders.
        Oncologist. 2013; 18: 301-307
        • Talmadge J.E.
        • Donkor M.
        • Scholar E.
        Inflammatory cell infiltration of tumors: Jekyll or Hyde.
        Cancer Metastasis Rev. 2007; 26: 373-400
        • Malcolm T.I.
        • Hodson D.J.
        • Macintyre E.A.
        • et al.
        Challenging perspectives on the cellular origins of lymphoma.
        Open Biol. 2016; 6: 1-12
        • Multhoff G.
        • Molls M.
        • Radons J.
        Chronic inflammation in cancer development.
        Front Immunol. 2011; 2: 98
        • Rauch D.
        • Gross S.
        • Harding J.
        • et al.
        T-cell activation promotes tumorigenesis in inflammation-associated cancer.
        Retrovirology. 2009; 6: 116
        • Bondurant S.
        • Ernster V.
        • Herdman R.
        Safety of silicone breast implants. National Academies Press, Washington, DC2000
        • Lazzeri D.
        • Agostini T.
        • Bocci G.
        • et al.
        ALK-1-negative anaplastic large cell lymphoma associated with breast implants: a new clinical entity.
        Clin Breast Cancer. 2011; 11: 283-296
        • Lechner M.G.
        • Megiel C.
        • Church C.H.
        • et al.
        Survival signals and targets for therapy in breast implant-associated ALK--anaplastic large cell lymphoma.
        Clin Cancer Res. 2012; 18: 4549-4559
        • Meza Britez M.E.
        • Caballero Llano C.
        • Chaux A.
        Periprosthetic breast capsules and immunophenotypes of inflammatory cells.
        Eur J Plast Surg. 2012; 35: 647-651
        • Xu S.
        • Cao X.
        Interleukin-17 and its expanding biological functions.
        Cell Mol Immunol. 2010; 7: 164-174
        • Wolfram D.
        • Rabensteiner E.
        • Grundtman C.
        • et al.
        T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis.
        Plast Reconstr Surg. 2012; 129: 327e-337e
        • Leung S.
        • Liu X.
        • Fang L.
        • et al.
        The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease.
        Cell Mol Immunol. 2010; 7: 182-189
        • Kadin M.E.
        • Morgan J.
        • Kouttab N.
        • et al.
        Comparative analysis of cytokines of tumor cell lines, malignant and benign effusions around breast implants.
        Aesthet Surg J. 2019; 40: 630-637
        • Kadin M.E.
        • Deva A.
        • Xu H.
        • et al.
        Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma.
        Aesthet Surg J. 2016; 36: 773-781
        • Yoo H.
        • Park J.U.
        • Chang H.
        Comprehensive evaluation of the current knowledge on breast implant associated-anaplastic large cell lymphoma.
        Arch Plast Surg. 2022; 49: 141-149
        • Ferrufino-Schmidt M.C.
        • Medeiros L.J.
        • Liu H.
        • et al.
        Clinicopathologic features and prognostic impact of lymph node involvement in patients with breast implant-associated anaplastic large cell lymphoma.
        Am J Surg Pathol. 2018; 42: 293-305
        • Stuver R.
        • Lewis N.E.
        • Ewalt M.D.
        • et al.
        First report of bilateral breast-implant associated anaplastic large cell lymphoma caused by identical T-cell clone.
        Leuk Lymphoma. 2022; 63: 2747-2750
        • Bautista-Quach M.A.
        • Nademanee A.
        • Weisenburger D.D.
        • et al.
        Implant-associated primary anaplastic large-cell lymphoma with simultaneous involvement of bilateral breast capsules.
        Clin Breast Cancer. 2013; 13: 492-495
        • Lillemoe H.A.
        • Miranda R.N.
        • Nastoupil L.J.
        • et al.
        Clinical manifestations and surgical management of breast implant-associated anaplastic large cell lymphoma: Beyond the NCCN guidelines.
        Ann Surg Oncol. 2022; 29: 5722-5729
        • Adrada B.E.
        • Miranda R.N.
        • Rauch G.M.
        • et al.
        Breast implant-associated anaplastic large cell lymphoma: sensitivity, specificity, and findings of imaging studies in 44 patients.
        Breast Cancer Res Treat. 2014; 147: 1-14
        • Chourmouzi D.V.T.
        • Drevelegas A.
        New spontaneous breast seroma 5 years after augmentation: a case report.
        Cases J. 2009; 2: 7126
        • Mazzocchi M.D.L.
        • Corrias F.
        • Scuderi N.
        A clinical study of late seroma in breast implantation surgery.
        Aesthet Plast Surg. 2012; 36: 97-104
        • Carty M.J.
        • Pribaz J.J.
        • Antin J.H.
        • et al.
        A patient death attributable to implant-related primary anaplastic large cell lymphoma of the breast.
        Plast Reconstr Surg. 2011; 128: 112e-118e
        • Chai S.M.
        • Kavangh S.
        • Ooi S.S.
        • et al.
        Anaplastic large-cell lymphoma associated with breast implants: A unique entity within the spectrum of peri-implant effusions.
        Diagn cytopathology. 2014; 42: 929-938
        • Farkash E.A.
        • Ferry J.A.
        • Harris N.L.
        • et al.
        Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls.
        J Hematop. 2009; 2: 237-244
        • Popplewell L.
        • Thomas S.H.
        • Huang Q.
        • et al.
        Primary anaplastic large-cell lymphoma associated with breast implants.
        Leuk Lymphoma. 2011; 52: 1481-1487
        • Smith T.J.
        • Ramsaroop R.
        Breast implant related anaplastic large cell lymphoma presenting as late onset peri-implant effusion.
        Breast. 2012; 21: 102-104
        • Talagas M.
        • Uguen A.
        • Charles-Petillon F.
        • et al.
        Breast implant-associated anaplastic large-cell lymphoma can be a diagnostic challenge for pathologists.
        Acta Cytol. 2014; 58: 103-107
        • George E.V.
        • Pharm J.
        • Houston C.
        • et al.
        Breast implant-associated ALK-negative anaplastic large cell lymphoma: a case report and discussion of possible pathogenesis.
        Int J Clin Exp Pathol. 2013; 6: 1631-1642
        • Singh E.
        • Frost E.
        • Morris E.J.
        • et al.
        Anaplastic lymphoma masquerading as breast abscess in a patient with silicone implants.
        Breast J. 2013; 19: 543-545
        • Li S.
        • Lee A.K.
        Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction?.
        Int J Clin Exp Pathol. 2009; 3: 117-127
        • Taylor C.R.
        • Siddiqi I.N.
        • Brody G.S.
        Anaplastic large cell lymphoma occurring in association with breast implants: review of pathologic and immunohistochemical features in 103 cases.
        Appl Immunohistochem Mol Morphol : AIMM. 2013; 21: 13-20
        • Medeiros L.J.
        • Marques-Piubelli M.L.
        • Sangiorgio V.F.I.
        • et al.
        Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship.
        Mod Pathol. 2021; 34: 2154-2167
        • Fleming D.
        • Stone J.
        • Tansley P.
        Spontaneous regression and resolution of breast implant-associated anaplastic large cell lymphoma: Implications for research, diagnosis and clinical management.
        Aesthet Plast Surg. 2018; 42: 672-678
        • Horna P.
        • Wang S.A.
        • Wolniak K.L.
        • et al.
        Flow cytometric evaluation of peripheral blood for suspected Sézary syndrome or mycosis fungoides: International guidelines for assay characteristics.
        Cytometry B, Clin cytometry. 2021; 100: 142-155
        • Kadin M.E.
        • Xu H.
        • Hunsicker L.M.
        • et al.
        Non-malignant CD30+ cells in contralateral peri-Implant capsule of patient with BIA-ALCL: A premalignant step?.
        Aesthet Surg J. 2021; 42: NP125-NP129
        • Oishi N.
        • Brody G.
        • Ketterling R.
        • et al.
        Genetic subtyping of breast implant-associated anaplastic large cell lymphoma.
        Blood. 2018; 132: 544-547
        • Lyapichev K.A.
        • Pina-Oviedo S.
        • Medeiros L.J.
        • et al.
        A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma.
        Mod Pathol. 2020; 33: 367-379
        • Horwitz S.M.
        • Ansell S.
        • Ai W.Z.
        • et al.
        T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
        J Natl Compr Canc Netw. 2022; 20: 285-308
        • Jaffe E.S.
        • Ashar B.S.
        • Clemens M.W.
        • et al.
        Best practices guideline for the pathologic diagnosis of breast implant-associated anaplastic large-cell lymphoma.
        J Clin Oncol. 2020; 38: 1102-1111
        • Turton P.
        • El-Sharkawi D.
        • Lyburn I.
        • et al.
        UK guidelines on the diagnosis and treatment of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG).
        J Plast Reconstr Aesthet Surg. 2021; 74: 13-29
        • Clemens M.W.
        • Horwitz S.M.
        NCCN Consensus guidelines for the diagnosis and management of breast implant-associated anaplastic large cell lymphoma.
        Aesthet Surg J. 2017; 37: 285-289
        • Clemens M.W.
        • Medeiros L.J.
        • Butler C.E.
        • et al.
        Complete surgical excision Is essential for the management of patients with breast implant-associated anaplastic large cell lymphoma.
        J Clin Oncol. 2016; 34: 160-168
        • Rodríguez-Pinilla S.M.
        • García F.J.S.
        • Balagué O.
        • et al.
        Breast implant-associated Epstein-Barr virus-positive large B-cell lymphomas: a report of three cases.
        Haematologica. 2020; 105: e412-e414
        • Boroumand N.
        • Ly T.L.
        • Sonstein J.
        • et al.
        Microscopic diffuse large B-cell lymphoma (DLBCL) occurring in pseudocysts: do these tumors belong to the category of DLBCL associated with chronic inflammation?.
        Am J Surg Pathol. 2012; 36: 1074-1080
        • Miranda R.N.
        Anaplastic large cell lymphoma involving the breast: a clinicopathologic study of 6 cases and review of the literature.
        Arch Pathol Lab Med. 2009; 133: 1383-1390
        • Smith B.K.
        • Gray S.S.
        Large B-cell lymphoma occurring in a breast implant capsule.
        Plast Reconstr Surg. 2014; 134: 670e-671e
        • Larrimore C.
        • Jaghab A.
        A rare case of breast implant-associated diffuse large B-cell lymphoma.
        Case Rep Oncological Med. 2019; 2019: 1801942
        • Geethakumari P.R.
        • Markantonis J.
        • Shah J.L.
        • et al.
        Breast implant-associated plasmablastic lymphoma: a case report and discussion of the literature.
        Clin Lymphoma Myeloma Leuk. 2019; 19: e568-e572
        • Evans M.G.
        • Miranda R.N.
        • Young P.A.
        • et al.
        B-cell lymphomas associated with breast implants: Report of three cases and review of the literature.
        Ann Diagn Pathol. 2020; 46: 151512
        • Aladily T.N.
        • Nathwani B.N.
        • Miranda R.N.
        • et al.
        Extranodal NK/T-cell lymphoma, nasal type, arising in association with saline breast implant: expanding the spectrum of breast implant-associated lymphomas.
        Am J Surg Pathol. 2012; 36: 1729-1734
        • Olsen D.L.
        • Keeney G.L.
        • Chen B.
        • et al.
        Breast implant capsule-associated squamous cell carcinoma: a report of 2 cases.
        Hum Pathol. 2017; 67: 94-100
        • Balzer B.L.
        • Weiss S.W.
        Do biomaterials cause implant-associated mesenchymal tumors of the breast? Analysis of 8 new cases and review of the literature.
        Hum Pathol. 2009; 40: 1564-1570
        • Clemens M.W.
        • Jacobsen E.D.
        • Horwitz S.M.
        2019 NCCN Consensus guidelines on the diagnosis and treatment of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL).
        Aesthet Surg J. 2019; 39: S3-S13
        • Evans M.G.
        • Medeiros L.J.
        • Marques-Piubelli M.L.
        • et al.
        Breast implant-associated anaplastic large cell lymphoma: clinical follow-up and analysis of sequential pathologic specimens of untreated patients shows persistent or progressive disease.
        Mod Pathol. 2021; 34: 2148-2153